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8-Quinolinecarboxylic acid → 8-[5-(5-Methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazol-2-yl]-quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 8-Quinolinecarboxylic acid | HCID 66582 | — |
| 反応物 | 5-Methyl-3-phenyl-4-isoxazolecarbohydrazide | HCID 727924 | — |
| 生成物 | 8-[5-(5-Methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazol-2-yl]-quinoline | HCID 67215409 | 49% |
反応手順
As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (200 mg, 0.92 mmol) was converted using quinoline-8-carboxylic acid instead of o-toluic acid to the title compound (SiO2, heptane:ethyl acetate=80:20 to 50:50, 160 mg, 49%) which was obtained as a white solid. MS: m/e=355.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07541372B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-5cd1d0717af94572a34daabf12d7b118 |
| 出典メモ | uspto-grants-2009_06 |