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5-Methyl-3-phenyl-4-isoxazolecarbohydrazide → 2-(4-Fluoro-2-methoxy-phenyl)-5-(5-methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Methyl-3-phenyl-4-isoxazolecarbohydrazide | HCID 727924 | — |
| 反応物 | 4-Fluoro-2-methoxybenzoic acid | HCID 2774545 | — |
| 生成物 | 2-(4-Fluoro-2-methoxy-phenyl)-5-(5-methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazole | HCID 16722645 | 49% |
反応手順
As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (2.00 g, 9.12 mmol) was converted using 4-fluoro-2-methoxy-benzoic acid instead of o-toluic acid to the title compound (SiO2, heptane:ethyl acetate:dichloromethane=70:10:20 to 40:40:20, 1.59 g, 49%) which was obtained as a white solid. MS: m/e=352.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07541372B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-ada36cb5d0974f17a38517d07cf24731 |
| 出典メモ | uspto-grants-2009_06 |