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5-Methyl-3-phenylisoxazole-4-carboxylic acid → 2-(5-Methyl-3-phenyl-isoxazol-4-yl)-5-thiophen-3-yl-[1,3,4]oxadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Methyl-3-phenylisoxazole-4-carboxylic acid | HCID 14343 | — |
| 反応物 | Thiophene-3-carbohydrazide | HCID 468648 | — |
| 生成物 | 2-(5-Methyl-3-phenyl-isoxazol-4-yl)-5-thiophen-3-yl-[1,3,4]oxadiazole | HCID 67215761 | 38% |
反応手順
As described for example 121, 5-methyl-3-phenylisoxazole-4-carboxylic acid (357 mg, 1.76 mmol) using thiophene-3-carboxylic acid hydrazide instead of thiophene-2-carboxylic acid hydrazide was converted to the title compound (SiO2, heptane:ethyl acetate=90:10 to 60:40, 207 mg, 38%) which was obtained as a yellow semisolid. MS: m/e=310.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07541372B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-68f5e694037b4fa8a3197d93ec079673 |
| 出典メモ | uspto-grants-2009_06 |