2-Aminothiazole → 2-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene

HRID 1983225

反応式

HRID 1983225 の反応式
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5][OH:6].F[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N+:22]([O-:24])=[O:23].[CH3:25][O:26][C:27]1[C:41]([O:42][CH3:43])=[C:40]([O:44][CH3:45])[CH:39]=[CH:38][C:28]=1[CH2:29][O:30][C:31]1[CH:37]=[CH:36][CH:35]=[CH:34][C:32]=1[NH2:33].[NH2:46][C:47]1[S:48][CH:49]=[CH:50][N:51]=1>>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5][O:6][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N+:22]([O-:24])=[O:23].[CH3:25][O:26][C:27]1[C:41]([O:42][CH3:43])=[C:40]([O:44][CH3:45])[CH:39]=[CH:38][C:28]=1[CH2:29][O:30][C:31]1[CH:37]=[CH:36][CH:35]=[CH:34][C:32]=1[NH:33][C:14]([NH:46][C:47]1[S:48][CH:49]=[CH:50][N:51]=1)=[O:13]

参加物

6

反応物 4

HCID 21552-AminothiazoleHCID 738951-Fluoro-2-nitrobenzeneHCID 123571(2,3,4-Trimethoxyphenyl)methanolHCID 669988422-(2,3,4-Trimethoxybenzyloxy)aniline2 回

生成物 2

HCID 59732707N-[2-(2,3,4-trimethoxybenzyloxy)phenyl]-N'-(thiazol-2-yl)urea収率 65%HCID 669989102-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene収率 72%

実験手順

2-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene (0.46 g, 72%) was prepared from 2,3,4-trimethoxybenzyl alcohol (0.35 ml, 2.0 mmol) and 1-fluoro-2-nitrobenzene (0.21 ml, 2.0 mmol) following the general procedure G. This was reduced to 2-(2,3,4-trimethoxybenzyl-oxy)aniline (0.26 g, 65%) following the general procedure B. N-[2-(2,3,4-trimethoxybenzyl-oxy)phenyl]-N′-(thiazol-2-yl)urea (240 mg, 65%) was prepared from 2-(2,3,4-trimethoxybenzyloxy)aniline (0.26 g, 0.9 mmol) and 2-aminothiazole (140 mg, 1.4 mmol) following the general procedure D.

出典と根拠

ORDレコード
ord-d903e9394e1e41a0a17f0b27147cddba
出典データセット
uspto-grants-2009_06
特許番号
US07541373B2

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