化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → N-[2-(3,4-Methylenedioxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Sesamol | HCID 68289 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-(3,4-Methylenedioxyphenoxy)aniline | HCID 28401891 | — |
| 生成物 | 2-(3,4-Methylenedioxyphenoxy)-1-nitrobenzene | HCID 7778939 | 58% |
| 生成物 | N-[2-(3,4-Methylenedioxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732860 | 68% |
反応手順
2-(3,4-Methylenedioxyphenoxy)-1-nitrobenzene (0.75 g, 58%) was prepared from 3,4-methylenedioxyphenol (0.76 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(3,4-methylenedioxyphenoxy)-aniline (0.47 g, 71%) following general procedure B. N-[2-(3,4-Methylenedioxyphenoxy)-phenyl]-N′-(thiazol-2-yl)urea (120 mg, 68%) was prepared from 2-(3,4-methylenedioxy-phenoxy)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07541373B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-ab0f8237c699496a9de2beb1551838d1 |
| 出典メモ | uspto-grants-2009_06 |