2-Aminothiazole → 3-Cyclopentylmethoxy-4-nitrotoluene

HRID 1983396

反応式

HRID 1983396 の反応式
[CH:1]1([CH2:6][OH:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.F[C:9]1[CH:10]=[C:11]([CH3:18])[CH:12]=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16].[CH:19]1([CH2:24][O:25][C:26]2[CH:32]=[C:31]([CH3:33])[CH:30]=[CH:29][C:27]=2[NH2:28])[CH2:23][CH2:22][CH2:21][CH2:20]1.[NH2:34][C:35]1[S:36][CH:37]=[CH:38][N:39]=1>>[CH:1]1([CH2:6][O:7][C:9]2[CH:10]=[C:11]([CH3:18])[CH:12]=[CH:13][C:14]=2[N+:15]([O-:17])=[O:16])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:19]1([CH2:24][O:25][C:26]2[CH:32]=[C:31]([CH3:33])[CH:30]=[CH:29][C:27]=2[NH:28][C:6]([NH:34][C:35]2[S:36][CH:37]=[CH:38][N:39]=2)=[O:7])[CH2:20][CH2:21][CH2:22][CH2:23]1

参加物

6

反応物 4

HCID 21552-AminothiazoleHCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 77195CyclopentanemethanolHCID 261895182-(Cyclopentylmethoxy)-4-methylaniline2 回

生成物 2

HCID 597328301-(2-Cyclopentylmethoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea収率 68%HCID 669989813-Cyclopentylmethoxy-4-nitrotoluene収率 70%

実験手順

3-Cyclopentylmethoxy-4-nitrotoluene (0.82 g, 70%) was prepared from cyclopentylmethanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 2-cyclopentylmethoxy-4-methyl-aniline (0.58 g, 81%) following general procedure C. 1-(2-Cyclopentylmethoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (225 mg, 68%) was prepared from 2-cyclopentylmethoxy-4-methyl-aniline (205 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

出典と根拠

ORDレコード
ord-b502c7275be947ee877f96211fca518e
出典データセット
uspto-grants-2009_06
特許番号
US07541373B2

関連ノート

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