HCID 68420482、化合物 → HCID 68419822、化合物

HRID 1983541ノート

反応式

HRID 1983541 の反応式
C(OC(=O)[NH:10][C:11]1[C:12]([O:49][CH3:50])=[C:13]2[C:17](=[CH:18][CH:19]=1)[N:16]([C:20]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[N:15]=[C:14]2[C:39]1[CH:48]=[CH:47][C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:40]=1)C1C=CC=CC=1>C(OCC)(=O)C.CO.[C].[Pd]>[CH3:50][O:49][C:12]1[C:11]([NH2:10])=[CH:19][CH:18]=[C:17]2[C:13]=1[C:14]([C:39]1[CH:48]=[CH:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[CH:40]=1)=[N:15][N:16]2[C:20]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

参加物

5

反応物 1

HCID 68420482HCID 68420482、化合物

生成物 1

HCID 68419822HCID 68419822、化合物収率 67.7%

試薬・触媒・溶媒 3

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

466 mg of (4-methoxy-3-naphthalen-2-yl-1-trityl-1H-indazol-5-yl)-carbamic acid benzyl ester obtained in Production Example II-38-a was dissolved in 20 ml of a 1:1 solvent mixture of ethyl acetate and methanol. 300 mg of 10% palladium-carbon was added and the mixture was subjected to catalytic hydrogenation at room temperature and normal atmospheric pressure. The reaction mixture was filtered through Celite, and the solvent was removed, to give 252 mg of the title compound.

後処理

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationThe reaction mixture was filtered through Celite
  3. customthe solvent was removed

出典と根拠

ORDレコード
ord-542ad14b73024eaa9aeaadcb226c5f98
出典データセット
uspto-grants-2009_06
特許番号
US07541376B2

反応ノート

読み込み中…