Morpholine → HCID 68853557、化合物

HRID 1984041ノート

反応式

HRID 1984041 の反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[NH:14][CH3:15])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>C(OCC)(=O)C>[CH3:15][NH:14][C:13]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]=1[S:2]([CH:18]1[O:19][CH2:20][CH2:21][NH:16][CH2:17]1)(=[O:4])=[O:3]

参加物

4

反応物 2

HCID 8083MorpholineHCID 57713890HCID 57713890、化合物

生成物 1

HCID 68853557HCID 68853557、化合物収率 30%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

3-(Chlorosulfonyl)-4-(methylamino)benzoic acid (1.2, 1.0 g) was dissolved in 20 mL of ethyl acetate and morpholine (Aa, 1.0 mL, 3 eq) was added. The mixture was stirred at room temperature for 2 hours, then extracted with 15 mL of 0.5M HCl. The organic layer was washed with H2O and brine, and the solvent evaporated to yield 4-(methylamino)-3-(morpholino-sulfonyl)-benzoic acid (1.3.Aa) as an off-white powder (0.30 g, 30% yield). MS analysis (m−1)=299.

後処理

  1. extractionextracted with 15 mL of 0.5M HCl
  2. washThe organic layer was washed with H2O and brine
  3. customthe solvent evaporated

出典と根拠

ORDレコード
ord-6d764d3af12242ccbf1626e48b87a39c
出典データセット
uspto-grants-2009_06
特許番号
US07544676B2

反応ノート

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