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Triethylamine → 1-(4-Methylpiperazin-1-yl)pent-4-yn-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | 4-Pentynoic acid | HCID 22464 | — |
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(4-Methylpiperazin-1-yl)pent-4-yn-1-one | HCID 57713812 | — |
反応手順
A solution of 4-pentynoic acid (519 mg, 5.29 mmol) and Et3N (737 μL, 5.29 mmol) in DCM (10 mL) was treated with ethyl chloroformate (504 μL, 5.29 mmol) at rt for 15 min. Then N-methyl-piperazine (588 μL, 5.29 mmol) was added, and stirring was prolonged for 45 min. Work-up (sat. aq. NaHCO3) and concentration gave the title compound as a colorless oil. 1H NMR (CDCl3) δ 3.63 (t, 2H), 3.48 (t, 2H), 2.55 (m, 4H), 2.38 (quint., 4H), 2.30 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07544672B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-4251d02f6efa41f88dd90cc28264d645 |
| 出典メモ | uspto-grants-2009_06 |