Piperazine → 1-(Pent-4-yn-1-yl)piperazine

HRID 1984090ノート

反応式

HRID 1984090 の反応式
CS(O[CH2:6][CH2:7][CH2:8][C:9]#[CH:10])(=O)=O.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>CCO>[CH2:6]([N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)[CH2:7][CH2:8][C:9]#[CH:10]

参加物

4

反応物 2

HCID 4837PiperazineHCID 12476209Pent-4-yn-1-yl methanesulfonate

生成物 1

HCID 866082211-(Pent-4-yn-1-yl)piperazine収率 24%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of pent-4-ynyl methanesulfonate (19.55 g) and piperazine (41.5 g) in EtOH (80 mL) was heated to reflux for 1 h, and evaporated. The residue was taken in NaOH 2M (70 mL) and extracted with Et2O (70 mL). Evaporation gave 1-(pent-4-ynyl)piperazine (4.4 g).

後処理

  1. temperatureto reflux for 1 h
  2. customevaporated
  3. extractionextracted with Et2O (70 mL)
  4. customEvaporation

出典と根拠

ORDレコード
ord-dee329d41fe746a599c186dee5dfe7d6
出典データセット
uspto-grants-2009_06
特許番号
US07544672B2

反応ノート

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