化工社化工社 化学情報印刷レポート · 研究参考用
Morpholine → (5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(morpholino)methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| 反応物 | 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid difluoropiperidine hydrochloride salt | HCID 131728197 | — |
| 生成物 | (5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(morpholino)methanone | HCID 11717680 | — |
反応手順
In analogy to the procedure described for the synthesis of intermediate 1, the title compound was synthesized from 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid difluoropiperidine hydrochloride salt with one equivalent of lithium chloride (intermediate 1, step 3) and morpholine. The title compound was obtained in 60% yield as off-white solid. MS (m/e): 372.5 (MH+, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745479B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-2703a310ed1e4bb19eed67233c4aa533 |
| 出典メモ | uspto-grants-2010_06 |