2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethanamine → 3-{2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethyl}aminomethyl-5-methylpyrazole

反応式

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[CH3:18][C:19]1[NH:23][N:22]=[C:21]([CH:24]=O)[CH:20]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][NH:17][CH2:24][C:21]3[CH:20]=[C:19]([CH3:18])[NH:23][N:22]=3)[CH2:13][CH2:14]2)=[CH:7][CH:8]=1

参加物

反応物 2

HCID 12561082-[4-(4-Methoxyphenyl)piperazin-1-yl]ethanamine

HCID 45602443-methyl-1H-pyrazole-5-carbaldehyde

生成物 1

HCID 160386363-{2-[4-(4-Methoxyphenyl)piperazin-1-yl]ethyl}aminomethyl-5-methylpyrazole収率 30.1%

実験手順

Compound 36 was prepared using the same method as that of Example 1 except that 4-(4-methoxyphenyl)piperazin-1-ylethylamine and 5-methylpyrazole-3-carbaldehyde were used.

出典と根拠

ORDレコード: ord-3dfb1a1d37bd46db96fcb8c2b9319fd1
出典データセット: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07544686B2

反応ノート

読み込み中…