m-Chloroperbenzoic acid → 4-[2-(Ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde

HRID 1984634

反応式

HRID 1984634 の反応式
[CH2:1]([S:3][C:4]1[N:5]=[CH:6][C:7]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:11]([C:20]3[CH:27]=[CH:26][C:23]([CH:24]=[O:25])=[CH:22][CH:21]=3)=[N:10][C:8]=2[N:9]=1)[CH3:2].ClC1C=C(C=CC=1)C(OO)=[O:33]>C(Cl)Cl>[CH2:1]([S:3]([C:4]1[N:5]=[CH:6][C:7]2[CH:13]=[C:12]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:11]([C:20]3[CH:21]=[CH:22][C:23]([CH:24]=[O:25])=[CH:26][CH:27]=3)=[N:10][C:8]=2[N:9]=1)=[O:33])[CH3:2]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 86078334HCID 86078334、化合物

生成物 1

HCID 577139404-[2-(Ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-[2-(ethylthio)-6-phenylpyrido[2,3-d]pyrimidine-7-yl]benzaldehyde (1.0 g, 2.69 mmol) in CH2Cl2 (30 mL) was added m-chloroperoxy benzoic acid (0.660 g, 3.0 mmol). The solution was stirred for 1 hr then quenched with sat. NaHCO3 and 10% Na2S2O3 and stirred for 30 min. The reaction mixture was diluted with CH2Cl2, extracted, dried with MgSO4, and filtered to afford the title compound. LRMS m/z (M+H) Calcd: 388.1 found: 388.1

後処理

  1. customthen quenched with sat. NaHCO3 and 10% Na2S2O3
  2. stirringstirred for 30 min
  3. additionThe reaction mixture was diluted with CH2Cl2
  4. extractionextracted
  5. dry with materialdried with MgSO4
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-0f35f60261fa43d5a0d2ea6c0ebdee00
出典データセット
uspto-grants-2009_06
特許番号
US07544677B2

関連ノート

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