関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-(2-(Dimethylamino)ethyl)piperazine | HCID 2736229 | — |
| 反応物 | 4-[2-(Ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde | HCID 57713940 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | HCID 57713955 | HCID 57713955 | — |
反応手順
To a solution of 4-[2-(ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde (6-4; 900 mg, 2.33 mmoles) in dioxane (1 mL) was added 1-(2-dimethylaminoethyl)-piperazine (66 mg, 2.33 mmoles) and heated to 150° C. in a microwave reactor for 30 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc) to give the title compound. LRMS m/z (M+H) Calcd: 467.2, found 467.6.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07544677B2 |
|---|
| 出典データセット | uspto-grants-2009_06 |
|---|
| ORD ID | ord-2f506c1a8a194f31a3b5d65708e32791 |
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| 出典メモ | uspto-grants-2009_06 |
|---|
