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HRID 1984637作成日：2026年10月27日
n,n-Dimethylpiperazine-1-carboxamide → 4-[7-(4-formylphenyl)-6-phenylpyrido[2,3-d]pyrimidin-2-yl]-N,N-dimethylpiperazine-1-carboxamide
https://huagongshe.com/reaction/1984637
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | n,n-Dimethylpiperazine-1-carboxamide | HCID 712909 | — |
| 反応物 | 4-[2-(Ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde | HCID 57713940 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-[7-(4-formylphenyl)-6-phenylpyrido[2,3-d]pyrimidin-2-yl]-N,N-dimethylpiperazine-1-carboxamide | HCID 57713959 | — |
反応手順
To a solution of 4-[2-(ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde (6-4; 100 mg, 0.258 mmole) in dioxane (1 mL) was added N,N-dimethylpiperazine-1-carboxamide (48 mg, 0.309 mmole) and heated to 150° C. in a microwave reactor for 30 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc) to give the title compound. LRMS m/z (M+H) Calcd: 467.2, found 467.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07544677B2 |
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| 出典データセット | uspto-grants-2009_06 |
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| ORD ID | ord-af3ea743f8a548be9a28127dfcf48c7f |
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| 出典メモ | uspto-grants-2009_06 |
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