反応式
[C:1]([C:3]1[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:5][O:6][C:7]=1[CH3:8])#[CH:2].I[C:16]1[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=1>>[CH3:8][C:7]1[O:6][N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:3]=1[C:1]#[C:2][C:16]1[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=1参加物
3
実験手順
As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (73 mg, 0.40 mmol) was converted (using 2-iodo-1-methyl-1H-imidazole instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 32 mg, 30%) which was obtained as a light brown solid. MS: m/e=264.2 [M+H]+.
出典と根拠
- ORDレコード
- ord-465f044ff8504f679b74e16890023e92
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07544704B2
関連ノート
読み込み中…