2-Bromo-4-ethylpyridine → 4-Ethyl-2-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-pyridine

HRID 1984681

反応式

HRID 1984681 の反応式
[C:1]([C:3]1[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:5][O:6][C:7]=1[CH3:8])#[CH:2].Br[C:16]1[CH:21]=[C:20]([CH2:22][CH3:23])[CH:19]=[CH:18][N:17]=1>>[CH2:22]([C:20]1[CH:19]=[CH:18][N:17]=[C:16]([C:2]#[C:1][C:3]2[C:4]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)=[N:5][O:6][C:7]=2[CH3:8])[CH:21]=1)[CH3:23]

参加物

3

反応物 2

HCID 41142482-Bromo-4-ethylpyridineHCID 534346474-Ethynyl-5-methyl-3-phenyl-isoxazole

生成物 1

HCID 247836684-Ethyl-2-(5-methyl-3-phenyl-isoxazol-4-ylethynyl)-pyridine収率 51%

実験手順

As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (92 mg, 0.50 mmol) was converted (using 2-bromo-4-ethylpyridine instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 74 mg, 51%) which was obtained as a yellow oil. MS: m/e=289.1 [M+H]+.

出典と根拠

ORDレコード
ord-49919e6f463a40da967f29e5d4249fa3
出典データセット
uspto-grants-2009_06
特許番号
US07544704B2

関連ノート

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