4-tert-Butylphenylboronic acid → HCID 58718060、化合物

反応式

Cl[C:2]1[CH:3]=[CH:4][C:5](OCCCCCCC)=[C:6]([CH:32]=1)[C:7]([NH:9][C@@H:10]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][C:24](OC(F)(F)F)=[CH:23][CH:22]=2)=[CH:17][CH:16]=1)[C:11]([OH:13])=[O:12])=[O:8].[C:41]([C:45]1[CH:50]=[CH:49][C:48](B(O)O)=[CH:47][CH:46]=1)([CH3:44])([CH3:43])[CH3:42]>>[C:18]1([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:19]=[CH:20][C:15]([CH2:14][C@H:10]([NH:9][C:7]([C:6]2[CH:32]=[C:2]([C:48]3[CH:49]=[CH:50][C:45]([C:41]([CH3:44])([CH3:43])[CH3:42])=[CH:46][CH:47]=3)[CH:3]=[CH:4][CH:5]=2)=[O:8])[C:11]([OH:13])=[O:12])=[CH:16][CH:17]=1

参加物

反応物 2

HCID 27343204-tert-Butylphenylboronic acid

HCID 58717891HCID 58717891、化合物

生成物 1

HCID 58718060HCID 58718060、化合物収率 86.5%

実験手順

3-Biphenyl-4-yl-(2S)-[(3-bromo-benzoyl-amino)-propionic acid (100 mg, 0.23 mmol) was reacted with 4-tert-butyl phenyl boronic acid (125 mg, 0.69 mmol) by following general procedure D yielding the title compound (95 mg) as a white solid.

出典と根拠

ORDレコード: ord-c63ea05b89a4494a902e7d0a977e6c5c
出典データセット: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07544699B2

反応ノート

読み込み中…