5-Bromosalicylic acid → 2-hydroxy-5-[4-(trifluoromethyl)phenyl]benzoic Acid
反応式
Br[C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:12][C:13]([F:24])([F:23])[C:14]1[CH:19]=[CH:18][C:17](B(O)O)=[CH:16][CH:15]=1>>[OH:11][C:5]1[CH:4]=[CH:3][C:2]([C:17]2[CH:18]=[CH:19][C:14]([C:13]([F:24])([F:23])[F:12])=[CH:15][CH:16]=2)=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]参加物
3
実験手順
5-Bromo-2-hydroxy-benzoic acid (5 g, 23.04 mmol) was reacted with 4-trifluoromethyl phenyl boronic acid (6.56 g, 34.5 mmol) as desribed in general procedure D. The crude product was then was then purified by silica gel column chromatography (ethyl acetate:hexanes from 20:80 to 60:40) to afford 4.5 g of the 4-hydroxy-4′-trifluoromethyl-biphenyl-3-carboxylic acid as a white solid.
後処理
- customThe crude product was then was then purified by silica gel column chromatography (ethyl acetate:hexanes from 20:80 to 60:40)
出典と根拠
- ORDレコード
- ord-01a81137d9ea4b5198f536bbaee2eca5
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07544699B2
反応ノート
読み込み中…