関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Theophylline | HCID 2153 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Diethyl(4-chlorobutyl)phosphonate | HCID 19689195 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Diethyl [4-(1,3-dimethylxanthin-7-yl)butyl]phosphonate | HCID 22446301 | — |
反応手順
10.9 g (0.05 mol) of 1,3-dimethylxanthine were suspended in 150 ml of DMF, treated with 13.7 g (0.06 mol) of diethyl 4-chlorobutanephosphonate and 7.0 g (0.05 mol) of activated potassium carbonate and heated at 70° C. for approximately 4 hours. The solid was then filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05728686 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-126b62e8f9c14b19bd96ee46b744d0b7 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
