4-Fluorophenylboronic acid → (4,4-Difluoro-piperidin-1-yl)-[1-(4-fluoro-phenyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

HRID 19853

反応式

HRID 19853 の反応式
[F:1][C:2]1([F:29])[CH2:7][CH2:6][N:5]([C:8]([C:10]2[NH:11][C:12]3[C:17]([CH:18]=2)=[CH:16][C:15]([O:19][CH:20]2[CH2:25][CH2:24][N:23]([CH:26]([CH3:28])[CH3:27])[CH2:22][CH2:21]2)=[CH:14][CH:13]=3)=[O:9])[CH2:4][CH2:3]1.[F:30][C:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=1>>[F:29][C:2]1([F:1])[CH2:7][CH2:6][N:5]([C:8]([C:10]2[N:11]([C:34]3[CH:35]=[CH:36][C:31]([F:30])=[CH:32][CH:33]=3)[C:12]3[C:17]([CH:18]=2)=[CH:16][C:15]([O:19][CH:20]2[CH2:25][CH2:24][N:23]([CH:26]([CH3:27])[CH3:28])[CH2:22][CH2:21]2)=[CH:14][CH:13]=3)=[O:9])[CH2:4][CH2:3]1

参加物

3

反応物 2

HCID 2856454-Fluorophenylboronic acidHCID 11603838(4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone2 回

生成物 1

HCID 67017920(4,4-Difluoro-piperidin-1-yl)-[1-(4-fluoro-phenyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

実験手順

In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 4-fluorobenzeneboronic acid. The title compound was obtained in 93% yield as yellow foam. MS (m/e): 500.2 (MH+, 100%).

後処理

  1. customIn analogy to the procedure described for the synthesis of example 6

出典と根拠

ORDレコード
ord-80f97b0bbe964f278bf1541c8d52b404
出典データセット
uspto-grants-2010_06
特許番号
US07745479B2

関連ノート

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