HCID 57719408、化合物 → HCID 57719830、化合物

HRID 1985392ノート

反応式

HRID 1985392 の反応式
[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([O:21][CH:22]([CH3:24])[CH3:23])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH:13]C(OC(C)(C)C)=O)[CH:7]=1>O1CCOCC1.Cl>[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([O:21][CH:22]([CH3:23])[CH3:24])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH2:13])[CH:7]=1

参加物

3

反応物 1

HCID 57719408HCID 57719408、化合物

生成物 1

HCID 57719830HCID 57719830、化合物収率 88.3%

試薬・触媒・溶媒 1

HCID 204431481,4-Dioxane hydrochloride溶媒

実験手順

1.034 g of 3-[3-(t-Butoxycarbonylaminomethyl)phenyl]-2(S)-isopropoxypropionic acid methyl ester was dissolved in 20 ml of hydrogen chloride 1,4-dioxane, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated, the residue was dissolved in ethyl acetate, and washed with saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 653 mg of the title compound as a colorless oil.

後処理

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with saturated aqueous sodium hydrogen carbonate
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-c6fbee78640042efb8b93a3afec12143
出典データセット
uspto-grants-2009_06
特許番号
US07544835B2

反応ノート

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