Hydrochloric Acid → 2,4,6-Trimethyl-5-hydroxypyrimidine

HRID 1985741ノート

反応式

HRID 1985741 の反応式
[CH3:1][C:2]1[O:3][C:4]([C:8](=O)[CH3:9])=[C:5]([CH3:7])[N:6]=1.[OH-].[NH4+:12].Cl>>[CH3:1][C:2]1[N:12]=[C:8]([CH3:9])[C:4]([OH:3])=[C:5]([CH3:7])[N:6]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 3184185-Acetyl-2,4-dimethyloxazole

生成物 1

HCID 1305522,4,6-Trimethyl-5-hydroxypyrimidine収率 60%

実験手順

The 2,4-dimethyl-5-acetyloxazole is poured into a Parr Bomb with 20 ml (51 mmol) of concentrated ammonium hydroxide and brought to 180° C. in three hours. Heating is continued for 10 hours, and after cooling the mixture is brought to pH 5 with HCl, extracted into ether, dried over Na2SO4 and stripped in vacuo. The residual solid is crystallized from benzene to give pale yellow crystals (1.3 g, 60%).

後処理

  1. temperatureHeating
  2. waitis continued for 10 hours
  3. temperatureafter cooling the mixture
  4. extractionextracted into ether
  5. dry with materialdried over Na2SO4
  6. customThe residual solid is crystallized from benzene

出典と根拠

ORDレコード
ord-f587ddf36fd74407b6758a4b3cc8b8fd
出典データセット
uspto-grants-2009_06
特許番号
US07547709B2

反応ノート

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