2-Amino-4-methylpyridine → N-[(4-methylpyridin-2-yl)carbamothioyl]benzamide

HRID 1985757

反応式

HRID 1985757 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[C:9]([N:17]=[C:18]=[S:19])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CC(C)=O>[C:9]([NH:17][C:18]([NH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1)=[S:19])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 15332-Amino-4-methylpyridineHCID 68284Benzoyl isothiocyanate

生成物 1

HCID 881443N-[(4-methylpyridin-2-yl)carbamothioyl]benzamide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 2-amino-4-methylpyridine (1.08 g, 10 mmol) and benzoyl isothiocyanate (1.63 g, 10 mmol) in acetone (15 mL) was stirred at RT for 1.5 h. The precipitate formed was filtered and washed with acetone to afford 1-benzoyl-3-[4-methylpyridin-2-yl]-thiourea as a solid. This material was stirred with 2 N NaOH solution (15 mL) at 110° C. for 1 h, then cooled to RT, and the precipitate formed was washed with water and dried to provide (4-methylpyridin-2-yl)-thiourea (0.90 g, 53%). MS m/z 168 (M+H)+.

後処理

  1. customThe precipitate formed
  2. filtrationwas filtered
  3. washwashed with acetone

出典と根拠

ORDレコード
ord-302fe9a461e84494bf6c4cc40a9d79b4
出典データセット
uspto-grants-2009_06
特許番号
US07547711B2

関連ノート

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