2-Bromopropanedial → 2-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde

HRID 1985758

反応式

HRID 1985758 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]([NH2:11])=[S:10])[CH:3]=1.Br[CH:13]([CH:16]=O)[CH:14]=[O:15].C([O-])(=O)C.[Na+]>C(O)(=O)C.O>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[S:10][C:13]([CH:14]=[O:15])=[CH:16][N:11]=2)[CH:3]=1

参加物

6

反応物 3

HCID 749452-BromopropanedialHCID 517045Sodium AcetateHCID 2760059(4-Methyl-pyridin-2-yl)-thiourea

生成物 1

HCID 220190842-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde収率 80%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of (4-methylpyridin-2-yl)-thiourea (334 mg, 2 mmol), 2-bromomalonaldehyde (302 mg, 2 mmol) and sodium acetate (250 mg, 3.0 mmol) in acetic acid (5 mL) was stirred at 100° C. for 3 h. The mixture was cooled to RT and diluted with water and the precipitate formed was collected, washed with water and dried to afford 2-(4-methylpyridin-2-ylamino)-thiazole-5-carbaldehyde (350 mg, 80%). MS m/z 220 (M+H)+.

後処理

  1. temperatureThe mixture was cooled to RT
  2. customthe precipitate formed
  3. customwas collected
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-baff89fb0ab445b085510ebfc367b3f6
出典データセット
uspto-grants-2009_06
特許番号
US07547711B2

関連ノート

読み込み中…