HCID 57720218、化合物 → HCID 57720313、化合物

HRID 1985849ノート

反応式

HRID 1985849 の反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]([CH2:15][O:16][C:17]1[CH:18]=[C:19]([CH:40]=[CH:41][CH:42]=1)[CH2:20][NH:21][C:22]1[N:26]([C@@H:27]2[O:33][C@H:32]([CH2:34][OH:35])[C@@H:30]([OH:31])[C@H:28]2[OH:29])[C:25]2[CH:36]=[CH:37][CH:38]=[CH:39][C:24]=2[N:23]=1)=[O:14])=O)(C)(C)C>Cl.C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]([CH2:15][O:16][C:17]1[CH:18]=[C:19]([CH:40]=[CH:41][CH:42]=1)[CH2:20][NH:21][C:22]1[N:26]([C@@H:27]2[O:33][C@H:32]([CH2:34][OH:35])[C@@H:30]([OH:31])[C@H:28]2[OH:29])[C:25]2[CH:36]=[CH:37][CH:38]=[CH:39][C:24]=2[N:23]=1)=[O:14]

参加物

3

反応物 1

HCID 57720218HCID 57720218、化合物

生成物 1

HCID 57720313HCID 57720313、化合物収率 72.4%

試薬・触媒・溶媒 1

HCID 21887872Ethanol hydrochloride溶媒

実験手順

2-{3-[(3-t-Butoxycarbonylaminopropylcarbamoyl)methoxy]benzylamino}-1-(β-D-ribofuranosyl)-1H-benzimidazole (15 mg) was dissolved in 22% hydrochloride-ethanol solution, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by preparative reverse phase column chromatography (Shiseido CAPSELL PAC C18UG80, 5 μm, 20×50 mm, flow rate 30 mL/minutes linear gradient, water/methanol=90/10-10/90) to give the title compound (9 mg).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe obtained residue was purified by preparative reverse phase column chromatography (Shiseido CAPSELL PAC C18UG80, 5 μm, 20×50 mm, flow rate 30 mL/minutes linear gradient, water/methanol=90/10-10/90)

出典と根拠

ORDレコード
ord-a18eec13e7d440dbafd25f187010e757
出典データセット
uspto-grants-2009_06
特許番号
US07547680B2

反応ノート

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