Sodium Bicarbonate → HCID 11194669、化合物
反応式
C(=O)([O-])O.[Na+].O.Cl.[C:8]([C:10]1[S:11][C:12]2[CH2:13][N:14]([CH3:19])[CH2:15][CH2:16][C:17]=2[N:18]=1)#[N:9]>O>[C:8]([C:10]1[S:11][C:12]2[CH2:13][N:14]([CH3:19])[CH2:15][CH2:16][C:17]=2[N:18]=1)#[N:9]参加物
4
実験手順
A solution of sodium hydrogencarbonate (272.33 mg) in water (5 mL) was added to 2-cyano-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride monohydrate (500.30 mg) at room temperature, and after all ingredients were completely dissolved, the resultant solution was extracted with toluene three times (10 mL×3). The toluene layers were combined, and the combined toluene layer was dried over sodium sulfate anhydrate (2.00 g). After any insoluble material was filtered off, the filtrate was concentrated at 40° C. under reduced pressure, to thereby give 384.28 mg of the title compound.
後処理
- dissolutionafter all ingredients were completely dissolved
- extractionthe resultant solution was extracted with toluene three times (10 mL×3)
- dry with materialthe combined toluene layer was dried over sodium sulfate anhydrate (2.00 g)
- filtrationAfter any insoluble material was filtered off
- concentrationthe filtrate was concentrated at 40° C. under reduced pressure
出典と根拠
- ORDレコード
- ord-fe269ef46f1740218c2d60b3e54ee1a5
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07547786B2
反応ノート
読み込み中…