1-tert-Butyloxycarbonyl-4-(3-aminopropyl)piperazine → 2-[5-Chloro-2-(3-piperazin-1-ylpropylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride

HRID 1986229

反応式

HRID 1986229 の反応式
[ClH:1].Cl.Cl.S1C(C2C=CN=C([NH:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][N:22](C)[CH2:21][CH2:20]3)N=2)=CC2C=CC=CC1=2.[CH:30]1([NH:33][C:34]([C:36]2[C:44]3[CH:43]=[C:42]([C:45]4[C:50]([Cl:51])=[CH:49][N:48]=[C:47](Cl)[N:46]=4)[S:41][C:40]=3[CH:39]=[CH:38][CH:37]=2)=[O:35])[CH2:32][CH2:31]1.C(OC(N1CCN(CCCN)CC1)=O)(C)(C)C>>[ClH:51].[ClH:1].[ClH:51].[CH:30]1([NH:33][C:34]([C:36]2[C:44]3[CH:43]=[C:42]([C:45]4[C:50]([Cl:51])=[CH:49][N:48]=[C:47]([NH:15][CH2:16][CH2:17][CH2:18][N:19]5[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]5)[N:46]=4)[S:41][C:40]=3[CH:39]=[CH:38][CH:37]=2)=[O:35])[CH2:32][CH2:31]1

参加物

4

反応物 3

HCID 177509451-tert-Butyloxycarbonyl-4-(3-aminopropyl)piperazineHCID 68855962[4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochlorideHCID 866253512-(2,5-Dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide

生成物 1

HCID 688588082-[5-Chloro-2-(3-piperazin-1-ylpropylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride

実験手順

Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is synthesized from 2-(2,5-dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and 4-(3-aminopropyl)-piperazine-1-carboxylic acid tert-butyl ester and isolated as a yellow solid (43% yield). ES+(m/z) 471 (35Cl) and 473 (37Cl) [M+H].

出典と根拠

ORDレコード
ord-9ca0ef3201844157afcb75cd78e588a6
出典データセット
uspto-grants-2009_06
特許番号
US07547691B2

関連ノート

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