1-(3-Aminopropyl)-4-methylpiperazine → 2-{5-Methyl-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophen-4-ol

HRID 1986246

反応式

HRID 1986246 の反応式
Cl.Cl.Cl.S1C(C2C=CN=C([NH:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)N=2)=CC2C=CC=CC1=2.Cl[C:31]1[N:36]=[C:35]([C:37]2[S:41][C:40]3[CH:42]=[CH:43][CH:44]=[C:45]([OH:46])[C:39]=3[CH:38]=2)[C:34]([CH3:47])=[CH:33][N:32]=1.NCCCN1CCN(C)CC1>>[CH3:47][C:34]1[C:35]([C:37]2[S:41][C:40]3[CH:42]=[CH:43][CH:44]=[C:45]([OH:46])[C:39]=3[CH:38]=2)=[N:36][C:31]([NH:15][CH2:16][CH2:17][CH2:18][N:19]2[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]2)=[N:32][CH:33]=1

参加物

4

反応物 3

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 68855962[4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochlorideHCID 1363439692-(2-Chloro-5-methylpyrimidin-4-yl)benzo[b]thiophen-4-ol

生成物 1

HCID 1363439702-{5-Methyl-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophen-4-ol

実験手順

Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is prepared from 2-(2-chloro-5-methylpyrimidin-4-yl)benzo[b]thiophen-4-ol and 1-(3-aminopropyl)-4-methylpiperazine and isolated as a solid. ES+(m/z) 398 [M+H].

後処理

  1. customisolated as a solid

出典と根拠

ORDレコード
ord-a9dfc7bd51974ca6ae67844a58dcff0b
出典データセット
uspto-grants-2009_06
特許番号
US07547691B2

関連ノート

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