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1-(3-Aminopropyl)-4-methylpiperazine → [4-(6-Bromobenzo[b]thiophen-2-yl)-5-methylpyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Aminopropyl)-4-methylpiperazine | HCID 78328 | — |
| 反応物 | [4-(Benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride | HCID 68855962 | — |
| 反応物 | 4-(6-Bromobenzo[b]thiophen-2-yl)-2-chloro-5-methylpyrimidine | HCID 86625374 | — |
| 生成物 | [4-(6-Bromobenzo[b]thiophen-2-yl)-5-methylpyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride | HCID 68856220 | — |
反応手順
Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is prepared from 4-(6-bromobenzo[b]thiophen-2-yl)-2-chloro-5-methylpyrimidine and 1-(3-aminopropyl)-4-methylpiperazine and isolated as a solid. ES+(m/z) 460 (79Br) and 462 (81Br) [M+H].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07547691B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-38ea2aa0a86446e19db7680f5c3a5637 |
| 出典メモ | uspto-grants-2009_06 |