1,5-bis(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinolinone → HCID 57722990、化合物

HRID 1987029ノート

反応式

HRID 1987029 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17]2[C:12](=[C:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH2:11][CH2:10][C:9]1=[O:27]>ClC1C=CC=CC=1.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:17]2[C:12](=[C:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH:11]=[CH:10][C:9]1=[O:27]

参加物

4

反応物 1

HCID 577229821,5-bis(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinolinone

生成物 1

HCID 57722990HCID 57722990、化合物収率 97%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 7964Chlorobenzene溶媒

実験手順

1,5-bis(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinolinone (0.85 g, 2.134 mmol) and manganese dioxide (5 g) were heated in chlorobenzene (50 ml) under reflux for 17 h. After cooling, the chlorobenzene was removed in vacuo, ethyl acetate (80 ml) added to the residue, then filtered through celite. The filtrate was evaporated in vacuo to afford the title compound as a yellow solid (0.82 g, 97%)

後処理

  1. temperatureunder reflux for 17 h
  2. temperatureAfter cooling
  3. customthe chlorobenzene was removed in vacuo, ethyl acetate (80 ml)
  4. additionadded to the residue
  5. filtrationfiltered through celite
  6. customThe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-bb2e8340f4bb4307a8995fc99d2d3f8c
出典データセット
uspto-grants-2009_06
特許番号
US07550480B2

反応ノート

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