Hydrochloric Acid → 4,5,5-Trifluoro-2-(prop-2-EN-1-YL)pent-4-EN-1-OL
反応式
[C:1](=[C:4]([CH2:6][CH:7]([CH2:13][CH:14]=[CH2:15])[CH2:8][O:9]COC)[F:5])([F:3])[F:2].CO.Cl>O>[C:1](=[C:4]([CH2:6][CH:7]([CH2:13][CH:14]=[CH2:15])[CH2:8][OH:9])[F:5])([F:3])[F:2]参加物
5
反応条件
- 温度
- 60 °C
実験手順
40 g of CF2═CFCH2CH(CH2OCH2OCH3)CH2CH═CH2 obtained in Example 3 and 100 mL of methanol were put into a 300 mL glass reactor, and a catalytic amount of concentrated hydrochloric acid was added thereto, followed by heating at 60° C. for 19 hours. The reaction solution was cooled to room temperature, and 30 mL of water was added to carry out liquid separation. The organic layer was further washed with 50 mL of water and subjected to precision distillation to obtain 35.3 g of CF2═CFCH2CH(CH2OH)CH2CH═CH2 (59-60° C./0.5 kPa).
後処理
- temperatureThe reaction solution was cooled to room temperature
- customliquid separation
- washThe organic layer was further washed with 50 mL of water
- distillationsubjected to precision distillation
出典と根拠
- ORDレコード
- ord-363678c7d2b34e12988f014078f041d8
- 出典データセット
- uspto-grants-2009_06
- 特許番号
- US07550545B2
反応ノート
読み込み中…