2,5 Dibromotoluene → 1,4-Dibromo-2-(bromomethyl)benzene

In a 250 ml three-necked round-bottom flask equipped with a reflux condenser, thermometer, dropping funnel with pressure-equalizing, and magnetic stirring bar, and containing 74.9 g (0.30 mol) of 3,6-dibromotoluene, 15.5 ml (47.9 g, 0.30 mmol) of bromine was added dropwise under exposure to 500 W lamp for 3 hours at 190° C. The resulting mixture was cooled to room temperature. Fractional distillation gave colorless liquid, b.p. 132-135° C./3 mm Hg. Yield 84.3 g (85%).

1. customIn a 250 ml three-necked round-bottom flask equipped with a reflux condenser
2. additionwas added dropwise under exposure to 500 W lamp for 3 hours at 190° C
3. distillationFractional distillation
4. customgave colorless liquid, b.p. 132-135° C./3 mm Hg

ORDレコード

ord-2a026eff71f54a3f9b4254f4cc11eeb9

出典データセット

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07550544B2