4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → HCID 67214733、化合物

反応式

[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][CH2:8][C:9]([CH3:12])([OH:11])[CH3:10])=[C:4]([O:15][CH3:16])[CH:3]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[C:26]([C:29](O)=[O:30])[NH:27][CH:28]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[C:26]([C:29]([NH:1][C:2]3[CH:14]=[CH:13][C:5]([O:6][CH2:7][CH2:8][C:9]([OH:11])([CH3:12])[CH3:10])=[C:4]([O:15][CH3:16])[CH:3]=3)=[O:30])[NH:27][CH:28]=2)=[CH:20][CH:19]=1

参加物

反応物 2

HCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid

HCID 67214703HCID 67214703、化合物

生成物 1

HCID 67214733HCID 67214733、化合物

実験手順

Acylation of 4-(4-amino-2-methoxyphenoxy)-2-methylbutan-2-ol from step A with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid to generate the title compound was achieved via the procedure described in step C of Example 1. The crude product was used for next step without further purification.

出典と根拠

ORDレコード: ord-6afda45b3e394bcfaa88d6bde1aa8240
出典データセット: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07553836B2

反応ノート

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