1,4-Dioxane → HCID 57725452、化合物

HRID 1988430ノート

反応式

HRID 1988430 の反応式
[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:34]=[CH:33][C:15]3[N:16]=[C:17]([NH:19][C@H:20]4[CH2:25][CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]4)[S:18][C:14]=3[CH:13]=2)[CH:8]=[CH:7][N:6]=1)=[O:4].O1CCOCC1>Cl>[CH3:1][NH:2][C:3](=[O:4])[C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:34]=[CH:33][C:15]3[N:16]=[C:17]([NH:19][C@H:20]4[CH2:25][CH2:24][CH2:23][NH:22][CH2:21]4)[S:18][C:14]=3[CH:13]=2)[CH:8]=[CH:7][N:6]=1

参加物

4

反応物 2

HCID 312751,4-DioxaneHCID 57725419HCID 57725419、化合物

生成物 1

HCID 57725452HCID 57725452、化合物収率 100%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

(S)-tert-butyl 3-(6-(2-(methylcarbamoyl)pyridin-4-yloxy)benzo[d]thiazol-2-ylamino)piperidine-1-carboxylate (56 mg, 0.12 mmol) was dissolved in 4 ml of 4M HCl in dioxane (16 mmol). The reaction solution was stirred at room temperature for 1 hour. The crude reaction solution was evaporated in vacuo to give (S)—N-methyl-4-(2-(piperidin-3-ylamino)benzo[d]thiazol-6-yloxy)picolinamide (46 mg, 0.12 mmol) as white solid. ES/MS m/z 384.0 (MH+).

後処理

  1. customThe crude reaction solution
  2. customwas evaporated in vacuo

出典と根拠

ORDレコード
ord-037c82874dd44e6fafc46bb01449562a
出典データセット
uspto-grants-2009_06
特許番号
US07553854B2

反応ノート

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