Diethyl Ether → 3-(3-Pyridinyl)benzoic acid hydrazide

HRID 1988782ノート

反応式

HRID 1988782 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10](OC)=[O:11])[CH:2]=1.[NH2:17][NH2:18].C(OCC)C>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10]([NH:17][NH2:18])=[O:11])[CH:2]=1

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 9321HydrazineHCID 4133188Methyl 3-(3-pyridinyl)benzoate

生成物 1

HCID 591273483-(3-Pyridinyl)benzoic acid hydrazide収率 35%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a stirred solution of methyl 3-(pyridin-3-yl)benzoate (190 mg, 0.89 mmol) in anhydrous methanol (1 mL) was added hydrazine (0.07 mL,). The solution was stirred at RT overnight before ethyl ether was added. The solid was filtered and washed with ethyl ether to give 67 mg (35% yield) of 3-(pyridin-3-yl)benzohydrazide as a white solid. An additional 120 mg of the product was recovered from the filtrate. (M+H)+=214.13

後処理

  1. additionwas added
  2. filtrationThe solid was filtered
  3. washwashed with ethyl ether

出典と根拠

ORDレコード
ord-db48da3c761946f89dc7e3ec82fda92f
出典データセット
uspto-grants-2010_01
特許番号
US07642273B2

反応ノート

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