Diethyl Ether → trans-2-(2-Chlorophenyl)cyclopropanemethanol

Pd(OAc)2 (13.3 mg, 0.06 mmol) was added to a solution of trans-3-(2-chlorophenyl)-2-propen-1-ol (100 mg, 0.59 mmol) in a solution of CH2N2 in Et2O (ca. 0.6 M, 25 mL). The reaction mixture was stirred at room temperature for 1 h. An additional amount of CH2N2 solution in Et2O (25 mL) was added and the mixture was stirred for 1 h. The mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography (CH2Cl2:(CH3)2CO, 95:5) to yield the title compound (85.5 mg, 79% yield).

1. stirringthe mixture was stirred for 1 h
2. filtrationThe mixture was filtered through diatomaceous earth
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was purified by flash chromatography (CH2Cl2:(CH3)2CO, 95:5)

ORDレコード

ord-629f55f13a5c4eb086865d394351dcef

出典データセット

uspto-grants-2010_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07642277B2