Ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate → 7-Bromo-4-hydroxycoumarin

HRID 1988889ノート

反応式

HRID 1988889 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[CH2:9][C:10]([O:12]CC)=O)=[C:4]([OH:16])[CH:3]=1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([C:8]([OH:15])=[CH:9][C:10](=[O:12])[O:16]2)=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 59127384Ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate2 回

生成物 1

HCID 546962297-Bromo-4-hydroxycoumarin収率 78.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate (Intermediate 30) (2.0 g) in dry toluene (20 ml) was stirred at reflux under nitrogen for 24 h. On cooling the resulting precipitate was collected by filtration, washed with ether and dried to give the title compound as a white solid (1.32 g).

後処理

  1. temperatureat reflux under nitrogen for 24 h
  2. temperatureOn cooling the resulting precipitate
  3. filtrationwas collected by filtration
  4. washwashed with ether
  5. customdried

出典と根拠

ORDレコード
ord-ca540a040e4345979095e68bbca15e30
出典データセット
uspto-grants-2010_01
特許番号
US07642276B2

反応ノート

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