6-Bromo-3-methyl-1,2-benzoxazole → 4-Methyl-3-(3-methyl-1,2-benzisoxazol-6-yl)-N-(1,3-thiazol-2-yl)benzamide

HRID 1988916ノート

反応式

HRID 1988916 の反応式
Br[C:2]1[CH:11]=[CH:10][C:5]2[C:6]([CH3:9])=[N:7][O:8][C:4]=2[CH:3]=1.[S:12]1[CH:16]=[CH:15][N:14]=[C:13]1[NH:17][C:18](=[O:35])[C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[C:21](B2OC(C)(C)C(C)(C)O2)[CH:20]=1>>[CH3:25][C:22]1[CH:21]=[CH:20][C:19]([C:18]([NH:17][C:13]2[S:12][CH:16]=[CH:15][N:14]=2)=[O:35])=[CH:24][C:23]=1[C:2]1[CH:11]=[CH:10][C:5]2[C:6]([CH3:9])=[N:7][O:8][C:4]=2[CH:3]=1

参加物

3

反応物 2

HCID 124113226-Bromo-3-methyl-1,2-benzoxazoleHCID 219145174-Methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(thiazol-2-yl)-benzamide2 回

生成物 1

HCID 104504804-Methyl-3-(3-methyl-1,2-benzisoxazol-6-yl)-N-(1,3-thiazol-2-yl)benzamide収率 7.5%

実験手順

Example 8 was prepared in a similar manner to Example 4 using 6-bromo-3-methyl-1,2-benzisoxazole (11 mg) and N-(thiazol-2-yl)-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (Intermediate 18, 17 mg) followed by purification via mass directed autoprep to give the title compound as an oil (1.3 mg).

後処理

  1. customfollowed by purification via mass

出典と根拠

ORDレコード
ord-04faeb0a5c8d4c938864c4c53e59ddbb
出典データセット
uspto-grants-2010_01
特許番号
US07642276B2

反応ノート

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