Phosphorus oxychloride → 2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine

反応式

[F:1][C:2]([F:21])([F:20])[C:3]1[NH:8][C:7](=O)[N:6]=[C:5]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[CH:4]=1.P(Cl)(Cl)([Cl:24])=O>>[Cl:24][C:7]1[N:8]=[C:3]([C:2]([F:21])([F:20])[F:1])[CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[N:6]=1

参加物

反応物 2

HCID 24813Phosphorus oxychloride

HCID 574686006-trifluoromethyl-4-(4-trifluoromethylphenyl)-1H-pyrimidin-2-one

生成物 1

HCID 574685992-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine

実験手順

The title compound was prepared from 6-trifluoromethyl-4-(4-trifluoromethylphenyl)-1H-pyrimidin-2-one (8.72 g, 28.3 mmol) and phosphoryl chloride (80 mL) according to the general procedure I. Obtained as a light brown solid (9.13 g, 98%). MS (EI) 326.0 [(M)+]; mp 71.5° C.

出典と根拠

ORDレコード: ord-94fba341e9424879ad159d45912f65c6
出典データセット: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07642264B2

反応ノート

読み込み中…

参加物