Phosphorus oxychloride → 2-Chloro-4-(3-methyl-4-trifluoromethyl-phenyl)-6-methyl-pyrimidine
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([CH3:18])[NH:15][C:14](=O)[N:13]=2)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].O=P(Cl)(Cl)[Cl:22]>>[Cl:22][C:14]1[N:13]=[C:12]([C:4]2[CH:5]=[CH:6][C:7]([C:8]([F:11])([F:10])[F:9])=[C:2]([CH3:1])[CH:3]=2)[CH:17]=[C:16]([CH3:18])[N:15]=1参加物
3
実験手順
The title compound was prepared from 4-(3-methyl-4-trifluoromethyl-phenyl)-6-methyl-1H-pyrimidin-2-one (1.73 g, 6.45 mmol) and phosphoroxychloride (20 mL) according to the general procedure I. Obtained as a brown solid (1.4 g, 76%). MS (EI) 286.1 [(M)+]; mp 101° C.
出典と根拠
- ORDレコード
- ord-0271d0a024a34bd788fcac4cb9b1057a
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07642264B2
反応ノート
読み込み中…