2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine → HCID 57468737、化合物

反応式

Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Br:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1>>[Br:19][C:20]1[N:21]=[CH:22][N:23]([C:2]2[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[CH:24]=1

参加物

反応物 2

HCID 574686142-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

HCID 178418934HCID 178418934、化合物

生成物 1

HCID 57468737HCID 57468737、化合物

実験手順

The title compound was prepared from 2-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example A.12) (2.73 g, 10.0 mmol) and commercially available 4-bromo-imidazole (2.21 g, 15.0 mmol) according to the general procedure IVa. Obtained as a light brown solid (3.20 g, 84%). MS (ISP) 383.0 [(M+H)+]; mp 166-168° C.

出典と根拠

ORDレコード: ord-bba6a6bd151c461c998093949ef25f7f
出典データセット: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07642264B2

反応ノート

読み込み中…

参加物