Diethyl Ether → N-(5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyridin-2-yl)-acetamide
反応式
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:6]=[C:5]([N:19]2[CH:23]=[C:22]([C:24]3[CH:25]=[CH:26][C:27]([NH2:30])=[N:28][CH:29]=3)[N:21]=[CH:20]2)[N:4]=1.[CH2:33]([O:35]CC)[CH3:34]>C(OC(=O)C)(=O)C>[F:32][C:2]([F:1])([F:31])[C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:18])[F:16])=[CH:11][CH:10]=2)[N:6]=[C:5]([N:19]2[CH:23]=[C:22]([C:24]3[CH:25]=[CH:26][C:27]([NH:30][C:33](=[O:35])[CH3:34])=[N:28][CH:29]=3)[N:21]=[CH:20]2)[N:4]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
A stirred solution of 5-{1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyridin-2-ylamine (example 13) (0.314 g, 0.7 mmol) in acetic acid anhydride (6 ml) was heated at 120° C. for 1 h. To the cooled reaction mixture was added diethyl ether (10 ml), the precipitate was collected by filtration and dried to yield the title compound as a light yellow solid (0.29 g, 84%). MS (ISP) 493.3 [(M+H)+]; mp 314° C.