2-Aminopyrimidine-5-boronic acid, pinacol ester → HCID 60209433、化合物

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=[C:10]([N:18]3[CH:22]=[C:21](I)[N:20]=[CH:19]3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[NH2:24][C:25]1[N:30]=[CH:29][C:28](B2OC(C)(C)C(C)(C)O2)=[CH:27][N:26]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=[C:10]([N:18]3[CH:22]=[C:21]([C:28]4[CH:27]=[N:26][C:25]([NH2:24])=[N:30][CH:29]=4)[N:20]=[CH:19]3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol ester

HCID 57468786HCID 57468786、化合物

生成物 1

HCID 60209433HCID 60209433、化合物

実験手順

The title compound was prepared from 4-(3-chloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-trifluoromethyl-pyrimidine (example E.72) (0.45 g, 1.0 mmol) and commercially available 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (0.26 g, 1.2 mmol) according to the general procedure VI. Obtained as a yellow solid (0.27 g, 65%). MS (ISP) 418.1 [(M+H)+]; mp 281° C.

出典と根拠

ORDレコード: ord-d006202c671340f087ae74c11cb0c5fc
出典データセット: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07642264B2

反応ノート

読み込み中…

参加物