化工社化工社 化学情報印刷レポート · 研究参考用
Cyclobutanone → 5-(1-Cyclobutyl-piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclobutanone | HCID 14496 | — |
| 反応物 | 5-(Piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester | HCID 67017921 | — |
| 生成物 | 5-(1-Cyclobutyl-piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester | HCID 67017902 | — |
反応手順
In analogy to the procedure described for the synthesis of example 43, step 7, the title compound was synthesized from 5-(piperidin-4-yloxy)-1-pyrimidin-5-yl-1H-indole-2-carboxylic acid ethyl ester (example 44, step 2) and cyclobutanone. The title compound was obtained in 58% yield as light yellow solid. MS (m/e): 421.1 (MH+, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745479B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-de48f38b6fee47caaefe5a4212650c77 |
| 出典メモ | uspto-grants-2010_06 |