関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 7-Ethoxymethyl-3-methylxanthine | HCID 13747684 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-Ethoxymethyl-1-ethyl-3-methylxanthine | HCID 19689194 | — |
反応手順
30 g (0.134 mol) of 7-ethoxymethyl-3-methylxanthine were suspended in 500 ml of absolute DMF with 25 g (0.161 mol) of ethyl iodide and 22.2 g (0.161 mol) of potassium carbonate and the mixture was stirred at 70° C. for 5 hours. The solution was filtered and the residue which remained was crystallized in diisopropyl ether. 28.7 g (85% of theory) of the title substance were obtained and employed without purification in Example 4b).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05728686 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-841b9089cd1f4520ba61b48f730e5eeb |
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| 出典メモ | uspto-grants-1998_03 |
|---|
