Ammonium Hydroxide → HCID 58727710、化合物

HRID 1992074ノート

反応式

HRID 1992074 の反応式
[Cl:1][C:2]1[N:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-].[NH4+:16]>>[NH2:16][S:11]([C:8]1[CH:9]=[N:10][C:2]([Cl:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5])(=[O:13])=[O:12]

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 574159692-Chloro-5-(chlorosulfonyl)pyridine-3-carboxylic acid

生成物 1

HCID 58727710HCID 58727710、化合物

実験手順

2-Chloro-5-(chlorosulfonyl)nicotinic acid (400 mg, 1.56 mmol) was stirred in a slurry of ice and excess ammonium hydroxide was added at 0° C. and stirred until all of the ice had melted. The resulting solution was evaporated to afford a white solid 5-(aminosulfonyl)-2-chloronicotinic acid. MS ES+ 237 (M+H). 1H NMR (400 MHz, DMSO-D6) δ ppm 8.1 (dd, J=2.6, 0.9 Hz, 1H), 8.6 (m, 1H).

後処理

  1. additionwas added at 0° C.
  2. customThe resulting solution was evaporated

出典と根拠

ORDレコード
ord-2cd57edea40a4b3f8c73a22d642c3ec2
出典データセット
uspto-grants-2010_01
特許番号
US07645771B2

反応ノート

読み込み中…