化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 4-aminobenzoate → Methyl 4-methanesulfonamidobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-aminobenzoate | HCID 12082 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | N,N-Diethyl-2-propanamine | HCID 521913 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 4-methanesulfonamidobenzoate | HCID 669159 | — |
反応手順
1.13 g (7.48 mmol) of methyl 4-aminobenzoate was dissolved in 20 mL of anhydrous DCM and 1.97 g (17.19 mmol) of mesyl chloride was added at 4 deg C., followed by the 2.22 g (17.19 mmol) of the diethylisopropylamine. Reaction was carried out overnight at room temperature resulting methyl 4-[(methylsulfonyl)amino]benzoate, which was used in the next step without additional purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07645771B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-7f5f7b731cca4810b466e6e67807f8d0 |
| 出典メモ | uspto-grants-2010_01 |