Triethylamine → N-(2-bromoethyl)-4-fluorobenzenesulfonamide
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Br.[Br:13][CH2:14][CH2:15][NH2:16].C(N(CC)CC)C>ClCCl.O>[Br:13][CH2:14][CH2:15][NH:16][S:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)(=[O:10])=[O:9]参加物
6
実験手順
4-Fluoro benzene sulfonyl chloride (8 g, 0.0411 mol) was added dropwise at 0° C. to a solution of 2-bromoethylamine hydrogen bromide (10.27 g, 0.0501 mol) and triethyl amine (14.3 ml, 0.1029 mol) in dry dichloromethane (100 ml) and stirred at room temperature for 1 h under nitrogen atmosphere. The reaction mixture was diluted with water and extracted with ethyl acetate. Organic layer was washed with water and brine and dried over sodium sulfate. Solvent evaporation under reduced pressure afforded the sub-title product as a liquid. Yield: 11 g
後処理
- extractionextracted with ethyl acetate
- washOrganic layer was washed with water and brine
- dry with materialdried over sodium sulfate
- customSolvent evaporation under reduced pressure
出典と根拠
- ORDレコード
- ord-6c84479aa6cf4876b0bc149ae09b6f2a
- 出典データセット
- uspto-grants-2010_01
- 特許番号
- US07648985B2
反応ノート
読み込み中…