Triethylamine → N-(3-Bromo-propyl)-4-cyano-benzenesulfonamide

HRID 1992357ノート

反応式

HRID 1992357 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].Br.[Br:14][CH2:15][CH2:16][CH2:17][NH2:18].C(N(CC)CC)C>ClCCl>[Br:14][CH2:15][CH2:16][CH2:17][NH:18][S:9]([C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1)(=[O:11])=[O:10]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 394974-Cyanobenzenesulfonyl chlorideHCID 787013-Bromopropylamine hydrobromide

生成物 1

HCID 43133733N-(3-Bromo-propyl)-4-cyano-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-Cyanobenzenesulfonyl chloride (5 g, 0.0248 mol) was added dropwise to a solution of 3-bromopropylamine hydrobromide (6.61 g, 0.0302 mol) and triethylamine (6.26 g, 0.062 mol) in dry dichloromethane (50 ml) at 0° C. and stirred at room temperature overnight under nitrogen atmosphere. The reaction was quenched with water and extracted with dichloromethane. The organic layer was washed with water, brine and dried over sodium sulfate.

後処理

  1. customThe reaction was quenched with water
  2. extractionextracted with dichloromethane
  3. washThe organic layer was washed with water, brine
  4. dry with materialdried over sodium sulfate

出典と根拠

ORDレコード
ord-3af1aa919d5c4a828056269fa8c41bc5
出典データセット
uspto-grants-2010_01
特許番号
US07648985B2

反応ノート

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